Quinone and hydroquinone lipids
Medchemexpress LLC BIMAX1 acetate | 1105053-45-9 | 96.1% | 3542.03 | 5 MG
BIMAX1 acetate is a tool peptide used in experiments to examine the interaction of RBBP4 with importin β1 and the effects on the nuclear import pathway. It can be used to study the role of RBBP4 in regulating nuclear import efficiency and cellular senescence.
- Examines the interaction of RBBP4 with importin β1
- Investigates effects on the nuclear import pathway
- Studies the role of RBBP4 in regulating nuclear import efficiency
- Used to study cellular senescence
Medchemexpress LLC Enfuvirtide acetate | 914454-00-5 | 99.89% | 4551.93 | 25 MG
Enfuvirtide acetate is an anti-HIV-1 fusion inhibitor peptide intended for research use only. It inhibits HIV p24 antigen and Gag gene expression in macrophages.
- Anti-HIV-1 fusion inhibitor peptide
- Effective concentration for 50% inhibition (IC50) is 23 ± 6 nM in a cell-cell fusion assay
- Enhances the anti-HIV (Bal) effect of various antiretrovirals
- In vivo, has a T1/2 of 3.8 hours
Medchemexpress LLC iso-VQA-ACC acetate | 99.48% | 625.63 (free base) | 25 MG
iso-VQA-ACC acetate is a substrate for constitutive proteasome. This chemical has a molecular weight of 625.63 (free base) and a purity of 99.48% by HPLC.
- Can be stored as a powder at -80°C for 2 years or -20°C for 1 year.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month.
- Requires sealed storage away from moisture.
- Soluble in DMSO at 100 mg/mL (requires ultrasonication).
Medchemexpress LLC Endoxifen (E-isomer) | 114828-90-9 | 98.0% | 373.49 | 1 ML
Endoxifen E-isomer, also known as E-Endoxifen, is an E-isomer of Endoxifen. It is an impurity found in the Endoxifen Z-isomer agent substance and exhibits antiestrogenic effects. This product is for research use only.
- Inhibits PGR gene expression in E2-induced MCF-7 cells in vitro.
Medchemexpress LLC CGGK acetate | 96.78% | 363.43 (free acid) | 5 MG
CGGK acetate is a control peptide of CAQK peptide. It is supplied as a white to off-white solid with a sequence of Cys-Gly-Gly-Lys. This peptide is soluble in DMSO at concentrations of 100 mg/mL or greater.
- High purity of 96.78%
- Molecular weight of 363.43 (free acid)
- Appearance as a solid
- Color is white to off-white
- Soluble in DMSO (≥ 100 mg/mL)
- Storage conditions: -80°C for 2 years or -20°C for 1 year (powder); -80°C for 6 months or -20°C for 1 month (in solvent)
Medchemexpress LLC Pramlintide acetate | 187887-46-3 | 99.9% | 3949.39 (free base) | 25 MG
Pramlintide acetate is a polypeptide analogue of human amylin. It acts as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.
- Inhibits the growth of HCT-116 and HT-29 cells in a dose-dependent manner
- Demonstrates synergistic antiproliferative effects when combined with 5-fluorouracil, Oxaliplatin, or Irinotecan
Medchemexpress LLC GLP-1(7-37) acetate | 1450806-98-0 | 99.6% | 3355.67 (free base) | 25 MG
GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
- Augments glucose-induced insulin secretion.
- Targets GCGR.
- Store powder sealed, away from moisture and light, at -80°C for 2 years or -20°C for 1 year.
- Store in solvent sealed, away from moisture and light, at -80°C for 6 months or -20°C for 1 month.
- Soluble in water and PBS.
Medchemexpress LLC Glp-1(7-37) acetate | 1450806-98-0 | 99.59% | 3355.67 (free base) | 5 MG
GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
- Insulinotropic hormone: augments glucose induced insulin secretion.
- This product is for research use only.
Medchemexpress LLC NN1213 acetate | 99.65% | 4553.10 (free base) | 25 MG
NN1213 acetate is a long-acting human amylin peptide analog and a selective Amylin receptor agonist. It has shown to significantly reduce food intake and fat mass, and can reduce body weight in diet-induced obese rats. This product is suitable for research related to obesity.
- Long-acting human amylin peptide analog
- Selective amylin receptor agonist
- Reduces food intake and fat mass
- Decreases body weight in diet-induced obese rats
- Used for obesity research
Apexbio Technology LLC Leuprolide Acetate(Synonyms: GnRH receptor agonist, Gonadotropin-Releasing Hormone receptor agonist, GnRH agonist), 25mg, CAS: 74381-53-6.
A3551 is a small molecule compound designed to modulate specific cellular signaling pathways implicated in various pathological states It functions primarily by targeting kinase-mediated pathways thereby influencing intracellular signaling cascades associated with cell proliferation and differentiation Due to its pathway-specific mechanism of action A3551 is valuable for biomedical research examining signal transduction mechanisms oncogenesis processes and potential therapeutic intervention strategies
Medchemexpress LLC Lefamulin (acetate) | 1350636-82-6 | 99.7% | 567.78 | 25 MG
Lefamulin (BC-3781) acetate is an orally active antibiotic. It inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. This product also exhibits anti-inflammatory activity and is used in the research of bacterial infections, such as bacterial pneumonia.
- Inhibitory activity against *C. trachomatis*, *N. gonorrhoeae*, and *M. genitalium* in vitro.
- Potent activity against *M. pneumoniae* strains with MIC values of ≤0.008 μg/mL.
- Shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse models in vivo.
- Demonstrates antibacterial effect in *S. pneumoniae* or *S. aureus* challenged lung infection mice.
Medchemexpress LLC (rel)-β-Tocopherol | 148-03-8 | 99.9% | 416.69 | 1 MG
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E that exhibits antioxidant activity. It is intended for research use only and not for human consumption.
- β-Tocopherol (50 μM, 48 hours) has been observed to slightly inhibit the proliferation of A7r5 cells (10% inhibition) and CHO cells (20% inhibition), while showing no inhibitory effect on HeLa cells.
- It also inhibits PMA-induced adhesion of human erythroleukemia (HEL) cells (11% inhibition) and the expression of integrins α4 and α5 on the cell surface when applied at 50 μM for 24 hours.
- Appearance: Solid-Liquid Mixture
- Color: Colorless to off-white
- In ethanol: 50 mg/mL (119.99 mM); requires sonication.
- In a solution of 10% Ethanol, 40% PEG300, 5% Tween-80, and 45% Saline: ≥ 1.25 mg/mL (3.00 mM) as a clear solution.
Medchemexpress LLC N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine acetate | 98.4% | 362.39 | 25 MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor and a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation, induces a dose-dependent cytotoxic response (mean IC50=1 μM), and induces apoptosis by activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
- Potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 of 6 nM.
- Inhibits FLT3 autophosphorylation.
- Induces dose-dependent cytotoxic response (mean IC50=1 μM).
- Induces apoptosis by activation of caspase 3.
- Inhibits growth of primary AML and MV4-11 cells in mice.
- Useful in research of acute myeloid leukemia (AML).
Medchemexpress LLC β-Tocopherol-d3 | 936230-75-0 | 419.70 | 25 MG
β-Tocopherol-d3 is a deuterium labeled analogue of vitamin E, known for its antioxidant properties. It plays a role in inhibiting tyrosinase activity and melanin synthesis. This compound can also counteract the inhibition of cell growth and PKC activity caused by d-alpha-tocopherol. Its stable heavy isotopes are utilized as tracers in drug development, with deuteration explored for its potential impact on drug pharmacokinetics and metabolic profiles.
- Exhibits antioxidant properties.
- Can inhibit tyrosinase activity and melanin synthesis.
- Prevents inhibition of cell growth and PKC activity caused by d-alpha-tocopherol.
- Incorporates stable heavy isotopes as tracers for quantification in drug development.
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Glutarylcarnitine-d9 chloride | 102636-82-8 | 95.0% | 320.81 | 2.5 MG
Glutarylcarnitine-d9 (chloride) is the deuterium labeled Glutarylcarnitine chloride. It is a diagnostic metabolite for malonic aciduria and glutaric aciduria type I, which are monitored in most tandem mass spectrometry newborn screening programs. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.